Resource Type:
Publication
Publication Type:
Journal Article
Title:
Fast gapped-read alignment with Bowtie 2.
Series Name:
Nature methods
Journal Abbreviation:
Nat Methods
Volume:
9
Issue:
4
Page Numbers:
357-9
Publication Year:
2012
Publication Date:
2012 Mar 04
DOI:
10.1038/nmeth.1923
ISSN:
1548-7105
EISSN:
1548-7105
Cross Reference:
PMID |
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Citation:
Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2.. Nature methods. 2012 Mar 04; 9(4):357-9.
Abstract:
As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Publication Model:
Electronic
Language:
English
Language Abbr:
eng
Journal Country:
United States