Fast gapped-read alignment with Bowtie 2.

Resource Type: 
Publication
Publication Type: 
Journal Article
Title: 
Fast gapped-read alignment with Bowtie 2.
Authors: 
Langmead B, Salzberg SL
Series Name: 
Nature methods
Journal Abbreviation: 
Nat Methods
Volume: 
9
Issue: 
4
Page Numbers: 
357-9
Publication Year: 
2012
Publication Date: 
2012 Mar 04
DOI: 
10.1038/nmeth.1923
ISSN: 
1548-7105
EISSN: 
1548-7105
Cross Reference: 
PMIDLoading content
Citation: 
Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2.. Nature methods. 2012 Mar 04; 9(4):357-9.
Abstract: 

As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.

Publication Model: 
Electronic
Language: 
English
Language Abbr: 
eng
Journal Country: 
United States